�Bruker Daltonics today is showcasing several new senior high performance mass spectrometry products and applications for proteomics at the 7th HUPO World Congress 2008:
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maXis� is the world's first high speed Ultra High Resolution TOF (UHR-TOF) mass spectrometer platform, and truly represents a revolution in tandem mass spectroscopic analysis.
maXis offers exceptional proteomics performance with sub-ppm mass accuracy, mountain resolution of 40,000 to 60,000 crosswise a broad mass range, outstanding sensitiveness and five orders of dynamic chain - all at the high spectral rate of 20 Hz for MS and MS/MS that is essential for quantitative proteomics and to take broad advantage of ultra-high performance liquid chromatography.
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ETD II is the next-generation electron transfer dissociation mental faculty for Bruker's
HCTultra� high capacity ion trap. It is based on a novel and compact nCI (negative chemical ionization) source with increased ETD/PTR reactant ion generation, resulting in rapid, confident characterization of PTMs such as phosphorylations or glycosylations at sub-fmol sensitivity. In combination with the major and underlying ETD efficiency and predisposition advantages of the spherical high capacity trap excogitation,
ETD II is intentional to provide the most sensitive, quickest and most robust ETD fragmentation. Due to
HCTultra's inherent m/z range of greater 3,000 and its superior mass resolution that can buoy resolve 3+ and 4+ charge states of peptides on-the-fly at full analytic speed, ETD/PTR on the
HCT-Ultra throne even be used for up to 12 kDa proteins and beyond.
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MALDI-TDS� Top-Down Sequencing (TDS) solution provides unparalleled levels of information from undigested proteins in pharmaceutical and biotechnology applications, including C- and N- terminal assignments even in the pillowcase of N-terminally blocked proteins.
MALDI-TDS is available on Bruker's top-of-the line
ultraflex� III TOF/TOF system for the characterization of PEGylation sites and other protein modifications of vital importance in fields such as recombinant protein yield, biologics drug development and quality restraint.
MALDI-TDS has clearly proved its utility in the recent ABRF Protein Research Group (PRG) 2008 Study for the identification and differentiation of various truncate proteins of the like origin and provided 100% protein episode coverage. Bruker's unique
SmartBeam� is the enabling engineering for
MALDI-TDS, complemented by next generation
BioTools 3.2 top-down bioinformatics.
-- The high sensitiveness
SmartBeam� MALDI ion funnel source has now been coupled with the ultra-high mass resolution
apex-ultra� FTMS, representing a 'perfect match' for MALDI small molecule tissue paper imaging, including drugs and metabolites from animals dosed at curative levels, e.g. at or below 5 mg/kg. With mass resolution greater than 900,000 (at 7 Tesla), the cluttered spectra produced in small-scale molecule MALDI imaging of tissue samples are readily resolved, allowing for the first time MALDI-MS imaging of modest molecules without the necessary to purpose MS/MS (SRM) for chemical background suppression. The high mass truth combined with Bruker's
SmartFormula� software mechanically provides heart formula determination for detected molecules. This new imagery solution promises to advance areas such as drug development and delivery, clinical and pathology research, as well as other areas such as lipidomics.
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EASY-nLC� is a Bruker-supported nanoscale LC system with 1D and 2D separation capabilities. Due to the true split-free gradient mix it avoids cumbersome maintenance, and guarantees robust, steady and honest operation.
EASY-nLC dramatically reduces total solvent consumption and enables fast separations with peak widths less than 5 securities and Exchange Commission. The control by Bruker's
Hystar� software system supports all proteomics applications on the maxis, micrOTOF-Q II, HCT ion trap, Flex MALDI and apex of the sun's way FTMS instrument series for complete, prison guard LC/MS/MS solutions.
The new Bruker mass spectrometry products and applications for proteomics will be presented throughout the HUPO conference with more than 30 scientific contributions. During two Bruker Daltonics' lunch seminars on Monday and Tuesday highborn "(R)evolution in Biomarker Discovery", a prestigious researcher's jury including Helmut Meyer (MPC Bochum), Andrew Pitt (Univ. Glasgow) and Ron Heeren (FOM Amsterdam) will submit talks detailing proteomics applications based on the novel developments.
Bruker Daltonics Executive Vice President Dr. Michael Schubert commented: "At this year's HUPO World Congress in Amsterdam, Bruker Daltonics is continuing its history of mart leading innovations and is proudly cathartic the maXis, an instrument with unprecedented, simultaneous heights speed and ultra-high resolution performance across a broad mass range. In plus, Bruker Daltonics is greatly expanding the capabilities of its existent products through the discharge of several important enhancements, as advantageously as raw and advanced applications."
For further information on the HUPO conference, please see www.hupo2008.org.
For more information about
Bruker Daltonics and
Bruker Corporation (NASDAQ: BRKR), please visit http://www.bdal.com and hTTP://www.bruker.com.
EASY-nLC(TM) is a trademark of Proxeon Biosystems, Denmark.
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